-
The Clinical Guidelines for Acute Uncomplicated Cystitis and Acute Uncomplicated Pyelonephritis
-
Ki Ho Kim, Jae Heon Kim, Seung-Ju Lee, Hong Chung, Jae Min Chung, Jae Hung Jung, Hyun Sop Choe, Hun Choi, Sun-Ju Lee, The Committee of The Korean Association of Urogenital Track Infection and Inflammation
-
Urogenit Tract Infect 2017;12(2):55-64. Published online August 31, 2017
-
-
-
 Abstract
 PDF
- To date, there has not been an establishment of guidelines for urinary tract infections, due to limited domestic data in Korea, unlike other North American and European countries. The clinical characteristics, etiology, and antimicrobial susceptibility of urinary tract infections vary from country to country. Moreover, despite the same disease, antibiotic necessary to treat it may vary from country to country. Therefore, it is necessary to establish a guideline that is relevant to a specific country. However, in Korea, domestic data have been limited, and thus, guidelines considering the epidemiological characteristics pertaining specifically to Korea do not exist. Herein, describe a guideline that was developed by the committee of The Korean Association of Urogenital Tract Infection and Inflammation, which covers only the uncomplicated urinary tract infections, as covering all parts in the first production is difficult.
-
The Antibiotic Susceptibility of Escherichia coli from Community-Acquired Uncomplicated Urinary Tract Infection: A Focused on Fosfomycin
-
Hyun-Sop Choe, Seung-Ju Lee, In Ho Chang, Tae-Hyoung Kim, Hong Chung, Jae Min Chung, Sang Don Lee, Jae Hung Jung, Ki Ho Kim, Seung Ki Min, Yong Gil Na, Hana Yoon, Ho Song Yu, Mi-Kyung Lee, Sun-Ju Lee
-
Urogenit Tract Infect 2017;12(2):77-81. Published online August 31, 2017
-
-
-
Abstract
PDF
- Purpose: To assess the antibiotic susceptibility of Escherichia coli from community-acquired uncomplicated urinary tract infection (UTI).
Materials and Methods: Between August and December of 2015, confirmed cases of E. coli as a pathogen of community-acquired uncomplicated UTI were collected and assessed for antibiotic susceptibility in 10 designated hospitals. Additional fosfomycin susceptibility test was performed by a central laboratory using the disk diffusion method.
Results: A total of 347 E. coli isolates were collected from urine samples of community-acquired uncomplicated UTIs patients. The susceptibility rates of antibiotics were as follows: amikacin 100.0% (347), imipenem 100.0% (347), ciprofloxacin 57.1% (198), cefotaxime 74.9% (260), ampicillin 30.0% (104), trimethoprim/sulfamethoxazole 66.9% (232), and fosfomycin 98.0% (340). All fosfomycin-resistant E. coli isolates were extended-spectrum β-lactamase (ESBL)-producing. In 85 cases of ESBL-producing E. coli, the fosfomycin susceptibility rate was 91.8% (78/85).
Conclusions: Fosfomycin may be a useful option for the treatment of community-acquired uncomplicated UTIs. Further studies evaluating the role of fosfomycin in the treatment of UTIs and its clinical efficacy are necessary.
-
2017 Guidelines of The Korean Association of Urogenital Tract Infection and Inflammation: Acute Uncomplicated Cystitis
-
Ki Ho Kim, Seung-Ju Lee, Yong-Hyun Cho, Hyun-Sop Choe, Yong Gil Na, Jae Heon Kim, Hong Chung, Jae Min Chung, Jae Hung Jung, Hoon Choi, Sun-Ju Lee
-
Urogenit Tract Infect 2017;12(1):3-6. Published online April 30, 2017
-
-
-
Abstract
PDF
- Acute uncomplicated cystitis is the most common urinary tract infection that mainly occurs in adult females, particularly sexually active young women and postmenopausal women. It is commonly observed in primary health care settings, including urology as well as obstetrics and gynecology; more than half of healthy adult women visit clinics and hospitals at least once in their lifetime due to acute uncomplicated cystitis. The most common bacterium causing this condition is Escherichia coli, followed by Staphylococcus saprophyticus, Klebsiella pneumoniae, Proteus mirabilis, and etc. Trimethoprim-sulfamethoxazole or fluoroquinolones have been used as an empirical antibiotic treatment. However, as fluoroquinolone-resistant organisms or extended spectrum beta-lactamase-producing organisms are becoming more prevalent worldwide, information on regional antibiotic resistance and guidelines on antibiotic use are becoming increasingly more desparate.
-
2017 Guidelines of The Korean Association of Urogenital Tract Infection and Inflammation: Recurrent Urinary Tract Infection
-
Seung-Ju Lee, Hyun-Sop Choe, Yong Gil Na, Ki Ho Kim, Jae Heon Kim, Hong Chung, Jae Min Chung, Jae Hung Jung, Hoon Choi, Sun-Ju Lee, Yong-Hyun Cho
-
Urogenit Tract Infect 2017;12(1):7-14. Published online April 30, 2017
-
-
-
Abstract
PDF
- Recurrent infection after an acute urinary tract infection (UTI) episode is common in adult women. It is onerous to both the patient and the physician to treat frequent recurrent UTI. Every time when UTI recurs, patients experience lower urinary tract symptoms, fatigue, and limitation in everyday life, while the physician has difficulty in counseling patients with a disease entity whose pathophysiology is less known. Currently, prophylactic treatment for recurrent UTI is limited, is ineffective in most cases, and sometimes accompanies unexpected side effects. In this guideline, we aimed to establish feasible and effective recommendations for the treatment of recurrent UTI in healthy adult women.
-
Infectious Complications after Prostate Biopsy: A Prospective Multicenter Prostate Biopsy Study
-
Eu Chang Hwang, Ho Song Yu, Seung Il Jung, Dong Deuk Kwon, Sun Ju Lee, Tae-Hyoung Kim, In Ho Chang, Hana Yoon, Bongsuk Shim, Kwang Hyun Kim, Donghyun Lee, Jung-Sik Huh, Dong Hoon Lim, Won Jin Jo, Seung Ki Min, Gilho Lee, Ki Ho Kim, Tae Hwan Kim, Seo Yeon Lee, Seung Ok Yang, Jae Min Chung, Sang Don Lee, Chang Hee Han, Sang Rak Bae, Hyun Sop Choe, Seung-Ju Lee, Hong Chung, Yong Gil Na, Seung Woo Yang, Sung Woon Park, Young Ho Kim, Tae Hyo Kim, Won Yeol Cho, June Hyun Han, Yong-Hyun Cho, U-Syn Ha, Heung Jae Park, The Korean Association of Urogenital Tract Infection and Inflammation (KAUTII)
-
Urogenit Tract Infect 2016;11(1):17-24. Published online April 30, 2016
-
-
-
Abstract
PDF
- Purpose: Recent studies have highlighted an increasing trend of infectious complications due to fluoroquinolone-resistant organisms among men undergoing transrectal prostate biopsy. This study evaluated the current incidence of infective complications after trans-rectal prostate biopsy for identification of risk factors in Korean men who received fluoroquinolone prophylaxis.
Materials and Methods: A prospective, multicenter study was conducted in Korea from January to December 2015. Prostate biopsies performed with fluoroquinolone prophylaxis during 3 months in each center were included. A pre-biopsy questionnaire was used for identification of patient characteristics. Clinical variables including underlying disease, antibiotic prophylaxis, enema, povidoneiodine cleansing of the rectum, and infectious complications were evaluated. The primary outcome was the post-biopsy infection rate after fluoroquinolone prophylaxis. Univariable and multivariable analyses were used for identification of risk factors for infectious complications.
Results: The study included 827 patients, of whom 93 patients (11.2%) reported receiving antibiotics in the previous 6 months and 2.5% had a history of prostatitis. The infectious complication rate was 2.2%. Post-biopsy sepsis was reported in 2 patients (0.2%). In multivariable analysis predictors of post-biopsy sepsis included person performing biopsy (adjusted odds ratio [OR], 4.05; 95% confidence interval [CI], 1.31-12.5; p=0.015) and operation history within 6 months (adjusted OR, 5.65; 95% CI, 1.74-18.2; p=0.004).
Conclusions: The post-prostate biopsy infectious complication rate in this study was 2.2%. Person performing biopsy (non-urologists) and recent operation history were independent risk factors for infectious complications after trans-rectal prostate biopsy.
-
Efficacy of Collatamp on Pediatric Urologic Surgery
-
Jeong Woo Yoo, Yeong Jin Seo, Kyung Seop Lee, Ki Ho Kim
-
Korean J Urogenit Tract Infect Inflamm 2015;10(1):36-40. Published online April 30, 2015
-
-
-
Abstract
PDF
- Purpose: The purpose of this study is to evaluate efficacy of Collatamp (EUSA Pharma [Europe]; a gentamicin-containing collagen implant, GCCI) in pediatric urologic surgery. Materials and Methods: The study comprised a retrospective analysis of 35 consecutive children who underwent pediatric urologic surgery for treatment of hydrocele, undescended testis and varicocele between March 2013 and March 2015. Collatamp containing 130 mg gentamicin and 280 mg collagen were immersed in 300 ml normal saline for up to 6 hours. At set times after immersion the GCCI were removed, the saline diluted in normal human serum and the gentamicin content assayed by a validated immunoassay (Cedia, Microgenics Ltd., UK) to provide an estimate of the loss from each implant. Patients were classified according to two groups: patients with Collatamp (group A) and those without Collatamp (group B). Postoperative complication, operative time and age, etc. were assessed at postoperative 7 days. Results: Sixteen hydrocele, 16 undescended testis, and 3 varicocele patients were identified, with a median age of 87.43±54.10 months, operation time of 103.60±29.41 minutes, and hospitalization period of 3.20±0.68 days. Mean age, operation time, and hospitalization period in group A, B was 64.81±60.32 months, 100.80±46.80 months (p=0.02), 122.30±40.70 minutes, 103.61±29.39 minutes (p=0.17), and 3.20±0.40 days, 3.20±0.80 days (p=0.67), respectively. No statistically significant differences in postoperative complication were observed between the two groups. However, cost was higher in group A than in group B (300,000 won vs, 15,900.82±3,905.72 won). Conclusions: Collatamp may be useful and effective in preventing wound infection in pediatric urologic surgery, although Collatamp is more expensive.
-
Non-Antibiotic Prophylaxis for Recurrent Urinary Tract Infections
-
Ki Ho Kim
-
Korean J Urogenit Tract Infect Inflamm 2014;9(1):9-13. Published online April 30, 2014
-
-
-
Abstract
PDF
- Urinary tract infections (UTI) are one of the most common infections affecting women. In a recent study of college women with their first UTI, 27% experienced at least one culture-confirmed recurrence within the six months following the initial infection and 2.7% had a second recurrence during this time period. Women with recurrent UTI have an increased susceptibility to vaginal colonization with uropathogens due to a greater propensity for them to adhere to their epithelial cells. Risk factors include frequent sexual intercourse, spermicide use, first UTI at an early age, and maternal history of UTI. Effectiveness of continuous or post-coital prophylaxis with low-dose antimicrobials or intermittent self-treatment with antimicrobials in management of recurrent uncomplicated UTIs in women has been demonstrated. However, antibiotics are the main driving force in development of antibiotic resistance and can lead to resistance of not only the causative microorganisms, but also the commensal flora. The increasing prevalence of Escherichia coli isolates (the most prevalent uropathogen) that are resistant to antimicrobial agents has stimulated interest in non-antibiotic methods for prevention of UTIs. We discuss the overall use of non-antibiotic methods for prevention of recurrent UTI, including the use of immunostimulant OM-89, a vaginal vaccine or estrogen, lactobacilli prophylaxis, and cranberry.
-
The Mechanism of Extended Spectrum β-Lactamase
-
Ki Ho Kim
-
Korean J Urogenit Tract Infect Inflamm 2012;7(2):89-98. Published online October 31, 2012
-
-
-
Abstract
PDF
- β-lactamases are the most widespread cause of bacterial resistance to β-lactam antibiotics, such as the penicillins and cephalosporins, and the mechanisms of these enzymes are intensely studied. The first β-lactamase was identified in an isolate of Escherichia coli in 1940. Many of the gram-negative bacteria possess a naturally occurring, chromosomally mediated β-lactamase, which probably assists the bacteria in finding a niche when faced with competition from other bacteria that naturally produce β-lactams. β-lactamases are classified into two major types on the basis of the main component of the active site: serineβ-lactamases and metallo-β-lactamases. Serineβ-lactamases are further classified into three classes: class A, C, and D; i.e.,metalloβ-lactamase is classified into class B. As is well known, the catalytic mechanism of serineβ-lactamases involves acylation and deacylation. In this paper, we have investigated the mechanisms of class A β-lactamase, most of which have extended spectrum β-lactamases belonging to that of the other classes B,C, and D β-lactamase. (Korean J UTII 2012;7:89-98)
-
Update of Non-gonococcal Urethritis
-
Ki Ho Kim, Young Jin Seo
-
Korean J Urogenit Tract Infect Inflamm 2011;6(1):25-31. Published online April 30, 2011
-
-
-
Abstract
PDF
- Urethritis in males not secondary to gonorrhea is classified as non-gonococcalurethritis (NGU). NGU is a common chlamydia-associated syndrome in men. However, Mycoplasma genitalium and Trichomonas vaginalis have been suggested as pathogens that cause NGU. In 20-30% of NGU cases, possible pathogens remain unidentified. Symptoms, if present, include mucopurulent or purulent discharge, dysuria, andurethral pruritis. Culture, nucleic acid hybridization tests, and nucleic acid amplification test are available for the detection of N. gonorrhoeae and C. trachomatis. Treatment should be initiated as soon as possible after diagnosis. Azithromycin and doxycycline are highly effective for chlamydial urethritis. However, infections with M. genitalium respond better to azithromycin.
-
Clinical Guideline of Chancroid
-
Jae Min Chung, Ki Ho Kim
-
Korean J Urogenit Tract Infect Inflamm 2010;5(1):13-17. Published online April 30, 2010
-
-
-
Abstract
PDF
- Chancroid is an acute localized, autoinoculable venereal disease caused by Haemophilus ducreyi, characterized clinically by painful ulceration at the site of incubation, and frequently accompanied by regional lymphadenopathy, and short incubation period. Chancroid is a cofactor for of human immunodeficiency virus (HIV) transmission, as are genital herpes and syphilis; high rates of HIV infection among patients who have chancroid occur in some countries. A definitive diagnosis of chancroid requires the identification of H. ducreyi on special culture media. The combination of a painful genital ulcer and tender suppurative inguinal adenopathy suggests the diagnosis of chancroid. Recommended regimens for chancroid in HIV-infected patients are either azithromycin, 1g as a single oral dose, or ceftriaxone, 250mg as a single intramuscular dose. After prompt treatment, close follow-up is essential.
-
Clinical Guideline of Chlamydia Trachomatis Infection
-
Ki Ho Kim
-
Korean J Urogenit Tract Infect Inflamm 2010;5(1):40-50. Published online April 30, 2010
-
-
-
Abstract
PDF
- Sexually transmitted diseases (STD) are a major public health problem because their incidence is increasing worldwide despite prevention campaigns and because they raise the risk of HIV infection. Chlamydia trachomatis is the most prevalent bacterial sexually transmitted infection. Several thousands of cases still remain undiagnosed. Chlamydia infections are most often asymptomatic and can cause pelvic inflammatory disease and infertility to women and epididymo-orchitis to men. At present, there is no guideline for management of chlamydia infection in our country so it will help the patients and physicians to treat chlamydia infection and to make the suitable guideline for our country that we know about recent trends of Chlamydia infection guideline. The objective of this study is to know about recent trends of Chlamydia infection guideline focusing on Scottish Intercollegiate Guidelines Network (SIGN) guideline publicated at 2009 and Center for Disease Control and Prevention (CDC) and Canadian guideline publicated at 2006 and World Health Organization (WHO) guideline publicated at 2003.
-
Clinical Analysis of Fournier's Gangrene 9 Cases
-
Jung Dam Gim, Ki Ho Kim
-
Korean J Urogenit Tract Infect Inflamm 2008;3(2):217-222. Published online October 31, 2008
-
-
-
Abstract
PDF
- "Purpose: Fournier's gangrene is a rare and rapidly progressive infection of the genitalia, perineum, and abdominal wall. The mortality rate from this infection ranges from 0 to 67 percent. One of the most important determinants of the overall outcome is early recognition and extensive surgical debridement combined with broad-spectrum antibiotics therapy. The aim of this study was to review the clinical outcomes of 9 consecutive patients who suffered with Fournier’s gangrene and the related medical literature to highlight the current status of this disease. Materials and methods: We retrospectively reviewed the medical records of 9 patients with the Fournier’s gangrene who had been treated at Dong-guk University Hospital between March 1999 and December 2007. Results: The mean age was 60 years (range: 38~82), and the male to female ratio was 8:1. The most common cause of Fournier’s gangrene was perianal abscess (n=6, 66.6%) and the most common disease associated with Fournier’s gangrene was diabetes mellitus (n=5, 55.5%). The most common cultured organisms were K pneumoniae and E. coli. We performed aggressive surgical debridement combined with broad spectrum antibiotics therapy. The potential ports of entry for the causuative bacteria were anorectum (66%), urinary tract (22%) and skin (11%) The number of surgical procedures per patient ranged between 1 and 7 (mean: 3.54). Diverting colostomy was required in 22.2% (n=2) of the cases. One of them had multiple debridement at the thigh. Suprapubic cystostomy and both orchiectomies were performed in 1patient, respectively. One patient died due to sepsis. Conclusions: Fournier’s gangrene is a life-threatening disease, but the mortality rate can be diminished via early diagnosis and aggressive surgical intervention. And the use of broadspectrum antibiotics is mandatory. "
|
KAUTI
