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Original Article The Antibiotic Susceptibility of Escherichia coli from Community-Acquired Uncomplicated Urinary Tract Infection: A Focused on Fosfomycin
Hyun-Sop Choe, Seung-Ju Lee, In Ho Chang, Tae-Hyoung Kim, Hong Chung, Jae Min Chung, Sang Don Lee, Jae Hung Jung, Ki Ho Kim, Seung Ki Min, Yong Gil Na, Hana Yoon, Ho Song Yu, Mi-Kyung Lee, Sun-Ju Lee
Urogenital Tract Infection 2017;12(2):77-81.

Published online: August 31, 2017
Department of Urology, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Suwon,
1Department of Urology, Chung-Ang University School of Medicine, Seoul,
2Department of Urology, Konkuk University School of Medicine, Chungju,
3Department of Urology, Pusan National University Yangsan Hospital, Yangsan,
4Department of Urology, Yonsei University Wonju College of Medicine, Wonju,
5Department of Urology, Dongguk University School of Medicine, Gyeongju,
6Department of Urology, National Police Hospital, Seoul,
7Department of Urology, Chungnam National University School of Medicine, Daejeon,
8Department of Urology, Ewha Womans University School of Medicine, Seoul,
9Department of Urology, Chonnam National University Medical School, Gwangju,
10Department of Laboratory Medicine, Chung-Ang University College of Medicine, Seoul,
11Department of Urology, Kyung Hee University Medical Center, Seoul, Korea
Received: 25 February 2017   • Revised: 22 April 2017   • Accepted: 6 May 2017
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Purpose: To assess the antibiotic susceptibility of Escherichia coli from community-acquired uncomplicated urinary tract infection (UTI).
Materials and Methods: Between August and December of 2015, confirmed cases of E. coli as a pathogen of community-acquired uncomplicated UTI were collected and assessed for antibiotic susceptibility in 10 designated hospitals. Additional fosfomycin susceptibility test was performed by a central laboratory using the disk diffusion method.
Results: A total of 347 E. coli isolates were collected from urine samples of community-acquired uncomplicated UTIs patients. The susceptibility rates of antibiotics were as follows: amikacin 100.0% (347), imipenem 100.0% (347), ciprofloxacin 57.1% (198), cefotaxime 74.9% (260), ampicillin 30.0% (104), trimethoprim/sulfamethoxazole 66.9% (232), and fosfomycin 98.0% (340). All fosfomycin-resistant E. coli isolates were extended-spectrum β-lactamase (ESBL)-producing. In 85 cases of ESBL-producing E. coli, the fosfomycin susceptibility rate was 91.8% (78/85).
Conclusions: Fosfomycin may be a useful option for the treatment of community-acquired uncomplicated UTIs. Further studies evaluating the role of fosfomycin in the treatment of UTIs and its clinical efficacy are necessary.

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    The Antibiotic Susceptibility of <em>Escherichia coli</em> from Community-Acquired Uncomplicated Urinary Tract Infection: A Focused on Fosfomycin
    Urogenit Tract Infect. 2017;12(2):77-81.   Published online August 31, 2017
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