Chancroid is an acute localized, autoinoculable venereal disease caused by Haemophilus ducreyi, characterized clinically by painful ulceration at the site of incubation, and frequently accompanied by regional lymphadenopathy, and short incubation period. Chancroid is a cofactor for of human immunodeficiency virus (HIV) transmission, as are genital herpes and syphilis; high rates of HIV infection among patients who have chancroid occur in some countries. A definitive diagnosis of chancroid requires the identification of H. ducreyi on special culture media. The combination of a painful genital ulcer and tender suppurative inguinal adenopathy suggests the diagnosis of chancroid. Recommended regimens for chancroid in HIV-infected patients are either azithromycin, 1g as a single oral dose, or ceftriaxone, 250mg as a single intramuscular dose. After prompt treatment, close follow-up is essential.