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- Original Article Infectious Complications after Prostate Biopsy: A Prospective Multicenter Prostate Biopsy Study
- Eu Chang Hwang, Ho Song Yu, Seung Il Jung, Dong Deuk Kwon, Sun Ju Lee, Tae-Hyoung Kim, In Ho Chang, Hana Yoon, Bongsuk Shim, Kwang Hyun Kim, Donghyun Lee, Jung-Sik Huh, Dong Hoon Lim, Won Jin Jo, Seung Ki Min, Gilho Lee, Ki Ho Kim, Tae Hwan Kim, Seo Yeon Lee, Seung Ok Yang, Jae Min Chung, Sang Don Lee, Chang Hee Han, Sang Rak Bae, Hyun Sop Choe, Seung-Ju Lee, Hong Chung, Yong Gil Na, Seung Woo Yang, Sung Woon Park, Young Ho Kim, Tae Hyo Kim, Won Yeol Cho, June Hyun Han, Yong-Hyun Cho, U-Syn Ha, Heung Jae Park, The Korean Association of Urogenital Tract Infection and Inflammation (KAUTII)
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Urogenital Tract Infection 2016;11(1):17-24.
Published online: April 30, 2016
Department of Urology, Chonnam National University Medical School, Gwangju,
1Kyung Hee University School of Medicine, Seoul,
2Chung-Ang University School of Medicine, Seoul,
3Ewha Womans University School of Medicine, Seoul,
4Jeju National University School of Medicine, Jeju,
5Chosun University School of Medicine, Gwangju,
6National Police Hospital, Seoul,
7Dankook University Medical College, Cheonan,
8Dongguk University School of Medicine, Gyeongju,
9Kyungpook National University School of Medicine, Daegu,
10Myongji Hospital, Seonam University, Goyang,
11Veterans Health Service Medical Center, Seoul,
12Pusan National University Yangsan Hospital, Yangsan,
13The Catholic University of Korea, Uijeongbu St. Mary’s Hospital, Uijeongbu,
14The Catholic University of Korea, St. Vincent’s Hospital, Suwon,
15Konkuk University School of Medicine, Chungju,
16Chungnam National University School of Medicine, Daejeon,
17Kwangju Christian Hospital, Gwangju,
18Soon Chun Hyang University Bucheon Hospital, Bucheon,
19Dong-A University College of Medicine, Busan,
20Hallym University Dongtan Sacred Heart Hospital, Hwaseong,
21The Catholic University of Korea, Yeouido St. Mary’s Hospital, Seoul,
22The Catholic University of Korea, Seoul St. Mary’s Hospital, Seoul,
23Sungkyunkwan University School of Medicine, Seoul, Korea
1Kyung Hee University School of Medicine, Seoul,
2Chung-Ang University School of Medicine, Seoul,
3Ewha Womans University School of Medicine, Seoul,
4Jeju National University School of Medicine, Jeju,
5Chosun University School of Medicine, Gwangju,
6National Police Hospital, Seoul,
7Dankook University Medical College, Cheonan,
8Dongguk University School of Medicine, Gyeongju,
9Kyungpook National University School of Medicine, Daegu,
10Myongji Hospital, Seonam University, Goyang,
11Veterans Health Service Medical Center, Seoul,
12Pusan National University Yangsan Hospital, Yangsan,
13The Catholic University of Korea, Uijeongbu St. Mary’s Hospital, Uijeongbu,
14The Catholic University of Korea, St. Vincent’s Hospital, Suwon,
15Konkuk University School of Medicine, Chungju,
16Chungnam National University School of Medicine, Daejeon,
17Kwangju Christian Hospital, Gwangju,
18Soon Chun Hyang University Bucheon Hospital, Bucheon,
19Dong-A University College of Medicine, Busan,
20Hallym University Dongtan Sacred Heart Hospital, Hwaseong,
21The Catholic University of Korea, Yeouido St. Mary’s Hospital, Seoul,
22The Catholic University of Korea, Seoul St. Mary’s Hospital, Seoul,
23Sungkyunkwan University School of Medicine, Seoul, Korea
Received: 10 March 2016 • Revised: 27 March 2016 • Accepted: 28 March 2016
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Abstract
Purpose: Recent studies have highlighted an increasing trend of infectious complications due to fluoroquinolone-resistant organisms among men undergoing transrectal prostate biopsy. This study evaluated the current incidence of infective complications after trans-rectal prostate biopsy for identification of risk factors in Korean men who received fluoroquinolone prophylaxis.
Materials and Methods: A prospective, multicenter study was conducted in Korea from January to December 2015. Prostate biopsies performed with fluoroquinolone prophylaxis during 3 months in each center were included. A pre-biopsy questionnaire was used for identification of patient characteristics. Clinical variables including underlying disease, antibiotic prophylaxis, enema, povidoneiodine cleansing of the rectum, and infectious complications were evaluated. The primary outcome was the post-biopsy infection rate after fluoroquinolone prophylaxis. Univariable and multivariable analyses were used for identification of risk factors for infectious complications.
Results: The study included 827 patients, of whom 93 patients (11.2%) reported receiving antibiotics in the previous 6 months and 2.5% had a history of prostatitis. The infectious complication rate was 2.2%. Post-biopsy sepsis was reported in 2 patients (0.2%). In multivariable analysis predictors of post-biopsy sepsis included person performing biopsy (adjusted odds ratio [OR], 4.05; 95% confidence interval [CI], 1.31-12.5; p=0.015) and operation history within 6 months (adjusted OR, 5.65; 95% CI, 1.74-18.2; p=0.004).
Conclusions: The post-prostate biopsy infectious complication rate in this study was 2.2%. Person performing biopsy (non-urologists) and recent operation history were independent risk factors for infectious complications after trans-rectal prostate biopsy.
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