Abstract

"Purpose: We studied the changes in the antibiotic resistance to the causative organisms of urinary tract infection (UTI) for recent 10 years in order to give some useful informations on the choice of adequate drugs in the treatment of UTI. Material and Methods: We retrospectively analysed 9,546 uropathogens and their antimicrobial resistance that had more than 105 cfu/ml in urine culture in 5,981 in- or out-patients from January 1996 to September 2005. Results: The incidence of UTI was highest in the 1st decade (20.3%). The common pathogens were E. coli (35.2%), Enterococcus (19.4%), Pseudomonas (10.5%), Staphylococcus (8.0%) and Klebsiella (6.7%) in order. The incidence of E. coli decreased from 38.3% in 1996 to 25.1% in 2005 but the incidence of Enterococcus and Pseudomonas increased from 17.4% to 27.5% and from 7.7% to 14.9%, respectively. For Gram negative isolates, the resistance to ampicillin was very high (81.8%) and the resistance to ciprofloxacin and trimethoprim/sulfamethoxazole (TMP/SMX) were 37.4% and 58.6%, respectively. For E. coli, the resistance of ampicillin, ciprofloxacin and TMP/SMX were 77.4%, 37.2% and 56.0%, respectively. Conclusions: E. coli was the most common organism causing UTI but we should be concerned about the increase of Gram positive organisms, especially Enterococcus. Resistance of ampicillin, TMP/SMX and ciprofloxacin at the empirical therapy for UTI should be reconsidered."

• Keywords: Urinary tract infection, Antibiotics, Resistance