Abstract

The rat model of experimental pyelonephritis has been developed assuming that the rat has vesicoureteral reflux natively. It is also believed that injecting the infecting micro-organism through the rat urethra may cause pyelonephritis and renal scarring. But, it has been reported that in some experimental pyelonephritis rat model, pyelonephritis dose not develop because vesicoureteral reflux does not occur constantally. I want to review the whole process of developing experimental pyelonephritis in rat model and find the problems which related to vesicoureteral reflux, developing pyelonephritis and analysing pathologic results.

• Keywords: Animal experimentation, Rat, Vesicoureteral reflux