A 30-year-old male admitted to our hospital with sudden onset shortness of breath, general weakness, dysuria, frequency, oligouria and fever. Abdominal and chest computed tomography revealed septic pulmonary embolism, multiple thrombi along right common iliac, internal iliac and femoral vein and large size prostatic abscess (right lobe>5 cm, left lobe>3.5 cm). We, therefore, diagnosed septic
pulmonary embolism secondary to prostate abscess. Abscess was drained by transurethral resection of prostate with appropriate antibiotics therapy. There were no postoperative complications with complete abscess resolution. Septic pulmonary embolism originated from urinary tract infection is rare. So we present a case report and the review of relevant literatures.