Malakoplakia is a rare chronic granulomatous disease, which was originally described in the urinary bladder, but can involve many other organs and soft tissues. Malakoplakia is often associated with immunosuppression or immunodeficiency and is believed to be caused by an alternation in the bacterial phagocytic system. Histologically, the presence of Michaelis-Gutmann bodies is pathognomonic. We report on a case of malakoplakia of the bladder in a 62-year-old female.