Urogenital Tract Infection

Review

Microbiome Analysis Using Next-Generation Sequencing in Urinary Tract Infections: Hyunho Han, Joo Yong Lee; Urogenit Tract Infect 2022;17(1):1-7. Published online April 30, 2022; DOI: https://doi.org/10.14777/uti.2022.17.1.1

In recent decades, the understanding of the genetic information of microbes and hosts has advanced considerably with the development of next-generation sequencing (NGS). For infectious diseases, genomic analysis can provide valuable information on the host disease susceptibility, microbial pathogenicity, and drug sensitivity. For urinary tract infections (UTI), NGS can reveal the pathogenic microbe and the dysbiosis of the urinary microbiome, which is a crucial factor in the pathogenesis of UTI and other urinary tract disorders. This review outlines the role of urinary microbiome dysbiosis in UTI, urinary stone disease, and cancer. Furthermore, the recent advances in NGS technologies for future applications in infectious disease research are described in detail.

Citations

Citations to this article as recorded by

Next-Generation Sequencing Supports Targeted Antibiotic Treatment for Culture Negative Orthopedic Infections
Ellie J C Goldstein, Ravina Kullar, Emanuele Chisari, James Snyder, Christopher Cooper, Javad Parvizi, Jason Sniffen
Clinical Infectious Diseases.2023; 76(2): 359. CrossRef

36 View
0 Download
1 Crossref

First
Prev
Page of 1
Next
Last

Search