Urogenital Tract Infection

Comprehensive Review of COVID-19 on Benign Prostate Hyperplasia Patient Symptoms: Joongwon Choi, Hong Jin Suh, Dong Hwan Lee, Tae-Kon Hwang, Jung Jun Kim; Urogenit Tract Infect 2022;17(2):31-35. Published online August 31, 2022; DOI: https://doi.org/10.14777/uti.2022.17.2.31

Abstract PDF Supplementary Material PubReader ePub: Since the outbreak of the global Coronavirus disease (COVID-19) pandemic in 2019, the number of confirmed cases has increased steadily worldwide. The most common symptom of COVID-19 (SARS-CoV-2) is respiratory symptoms. On the other hand, increased voiding frequency and lower urinary tract symptoms (LUTS) have also been reported. Regarding the relationship between LUTS and COVID-19, only small size (n<100) retrospective studies have been reported, but the post-International Prostate Symptom Score (IPSS) increases compared to pre-IPSS after a COVID-19 infection in those older than 50 years. α-blockers and phosphodiesterase-5 inhibitors are relatively safe, but there are conflicting reports on 5α-reductase inhibitors; hence, further research is needed. Four major theories have been argued regarding the relationship between LUTS and COVID-19: renin-angiotensin system-related, androgen-related, inflammation-related, and metabolic derangement-related. In conclusion, elderly male patients often have benign prostate hyperplasia as a co-morbidity, and the severity of COVID-19 is high in this group. Therefore, voiding symptoms in these patient groups is of particular concern.

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Pilot Study of Cystochon^® (Cranberry Extract, Chondroitin Sulfate, and Hyaluronic Acid Complex) in Interstitial Cystitis/Bladder Pain Syndrome: Kwang Taek Kim, Jeong Woo Lee, Hyun-Sop Choe; Urogenit Tract Infect 2022;17(2):36-41. Published online August 31, 2022; DOI: https://doi.org/10.14777/uti.2022.17.2.36

Purpose: This study examined whether Cystochon^® (cranberry extract, chondroitin sulfate, and hyaluronic acid complex) effectively improves the symptoms and problems of interstitial cystitis/bladder pain syndrome (IC/BPS) patients.
Materials and Methods: From December 2021 to May 2022, the medical records of IC/BPS patients who visited St. Vincent’s Hospital, Kyung Hee University Medical Center, or Gachon University Gil Medical Center were collected. For the treatment of IC/BPS, the patients were given pentosan polysulfate (PPS) for 12 weeks, with Cystochon^® then added and maintained for an additional eight weeks. The OʼLeary–Sant symptom and problem index (Interstitial Cystitis Symptom Index [ICSI], Interstitial Cystitis Problem Index [ICPI]) was used to measure the treatment response.
Results: After 12 weeks of PPS treatment, ICSI and ICPI improved in all patients. After adding Cystochon^® for eight weeks, the ICSI and ICPI indicators improved further. In the ICSI category, significant improvement in symptoms was confirmed in the total ICSI score, particularly in the Q4 (pain-related) questionnaire after adding Cystochon^®. In the ICPI category, significant problem improvement was confirmed in the total ICPI score, particularly in the Q1 (frequent urination) and Q4 (pain-related) questionnaires. Although not statistically significant, the remaining indicators generally tended to improve.
Conclusions: The orally administered combination of cranberry extract, chondroitin sulfate, and hyaluronic acid (Cystochon^®) may have a clinically positive effect in patients with IC/BPS. Better clinical improvement can be expected when it is added to the PPS treatment, especially in the category of bladder pain.

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Anti-inflammatory effect of sea buckthorn in an HCl-induced cystitis rat model
Hyun Suk Yoon, Juyeon Yu, Shinhoon Kang, Hana Yoon
Investigative and Clinical Urology.2025; 66(1): 67. CrossRef
Pharmacological Properties of Shionone: Potential Anti-Inflammatory Phytochemical against Different Diseases
Varun Jaiswal, Hae-Jeung Lee
Molecules.2023; 29(1): 189. CrossRef

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Changes of Causative Organism and Antimicrobial Resistance in Urinary Tract Infections After the COVID-19: Young Ho Choi, Jong Hyun Tae, Mi-Kyung Lee, Tae-Hyoung Kim; Urogenit Tract Infect 2022;17(2):42-49. Published online August 31, 2022; DOI: https://doi.org/10.14777/uti.2022.17.2.42

Abstract PDF PubReader ePub: Purpose: During the coronavirus disease 2019 (COVID-19) pandemic, several studies reported changes in the distribution of microorganisms that cause major legal, respiratory, and gastrointestinal infectious diseases and increases in the antimicrobial resistance rates in Korea. On the other hand, there has been little domestic research on the causative organism of urinary tract infection (UTI). This study investigated the influence of the COVID-19 pandemic on the distribution of causative organisms and the antimicrobial resistance rate in UTI.
Materials and Methods: This study analyzed 17,201 urine cultures retrospectively from patients who visited Chung-Ang University Hospital from January 2018 to December 2021. Tests were then conducted to determine if there was a significant difference between the data for the eight quarters of the pre-COVID-19 period (January 2018 to December 2019) and the data for the eight quarters post-COVID-19 period (January 2020 to December 2021).
Results: Escherichia coli was the most common causative organism in all periods, but it decreased in the post-COVID-19 period. Enterococcus faecalis increased in the post-COVID-19 period. The ciprofloxacin resistance rate of E. coli and Klebsiella pneumoniae increased, but the ciprofloxacin and levofloxacin resistance rate of E. faecalis decreased.
Conclusions: There was little difference in the causative organism distribution of UTI and antimicrobial resistance rates before and after the COVID-19 pandemic. On the other hand, changes in some causative organisms are identified. Nevertheless, because this study was limited to a single medical institute, data from a broader spectrum of bacterial species collected from multiple institutions will be needed to obtain definitive results.

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An Unusual Case of Testicular Seminoma Mimicking Segmental Testicular Infarction: Young-Joo Kim; Urogenit Tract Infect 2022;17(2):50-52. Published online August 31, 2022; DOI: https://doi.org/10.14777/uti.2022.17.2.50

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Seminoma is the most common testicular tumor that commonly presents as a solid mass without pain. It generally shows high blood flow on Doppler ultrasonography (US). We report an atypical case of a painful testicular seminoma without vascularity on Doppler US that could be misdiagnosed as a segmental testicular infarction due to testicular torsion or epididymo-orchitis.

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Infarction of Paratesticular Inflammatory Myofibroblastic Tumor Mimicking Testicular Torsion
Trevor D. Fachko, James H. Hoang, Catherine L. Robey, Alice Werner, Sarah H. Williamson, Janelle A. Fox
Urology.2023; 182: e249. CrossRef

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