Effective strategies to prevent transmission or reduce the prevalence of resistant bacteria in hospitals include reducing antibiotic use, using antibiotics for which there is no resistance, decreasing length of hospital stays, instituting infection control measures to disrupt the spread of bacteria, nonspecific interventions that reduce transmission of all bacteria within a hospital, educating the hospitalstaff about the epidemiology, pathogenesis, and general routes of transmission of resistant bacteria. These strategies should adapt special situation (surgery patients, long-term admission/adult patients,pediatric patients). (Korean J UTII 2006;1:23?6)