This case report describes an uncommon case of renal actinomycosis in a 63-year-old man. The patient underwent radical nephrectomy for suspicious renal cell carcinoma with renal vein thrombosis and spinal metastasis. The postoperative diagnosis of renal and spinal actinomycosis was established in accordance with the results from histological examination. Three years after surgery, the patient did not show any symptoms of recurrence.