Encrusted cystitis and pyeloureteritis are rare chronic infectious conditions characterized by mucosal inflammation and encrustations of the urinary tract. It is caused by fastidious growing urea splitting microorganisms, mainly Corynebacterium. Herein, we report an unusual case of an 80-year-old man with encrusted cystitis and pyeloureteritis who was previously treated with transcatheteral arterial chemoembolization for hepatocellular carcinoma. Abdomino-pelvic computerized tomography showed a bilateral hydronephrosis with calcifications of renal pelvis, ureter, and bladder. Cystoscopy showed calcified bladder mucosa with necrosis and bleeding. After transurethral removal of calcified plaques, the patient was treated with antibiotic and oral urine acidification. One-month follow-up cystoscopy showed that inflammation was improved and calcification was significantly reduced.