Abstract

Purpose: In clinical settings, patients with asymptomatic pyuria were common undergoing transrectal ultrasonography prostate needle biopsy (TRUSBx). The purpose of this study was to analyze the effects of asymptomatic pyuria on the occurrence of complications of TRUSBx. Materials and Methods: A total of 1,054 patients underwent TRUSBx from January 2007 to December 2011. For these patients, complications, presence of asymptomatic pyuria, anti-coagulant usage, TRUSBx history, previous hospitalization within 1 month, prostate volume, diabetes, types of prophylactic antibiotics (quinolone or 3rd generation cephalosporin), and biopsy results were compared and analyzed. Results: Of 1,054 cases, 26 (2.5%) developed complications requiring treatment. Seven cases (0.7%) had gross hematuria, 10 cases (0.9%) had dysuria, 7 cases (0.7%) had acute urinary retention, and 2 cases (0.2%) had sepsis. Asymptomatic pyuria was shown in 353 cases (33.4%). Complication rate of asymptomatic pyuria cases was 4.2% compared with 1.6% for non-pyuria cases (p=0.011). Higher complication rate was also observed in cases with previous TRUSBx history (p<0.001), hospitalization within 1 month (p< 0.001), and diabetes (p<0.001). However prostate volume, use of anticoagulant, type of antibiotics, and presence of prostate cancer were not significantly different. In multivariate analysis, previous TRUSBx history, hospitalization within 1 month, and diabetes were statistically significant with higher complication rate. Conclusions: A high incidence of complications was observed for previous TRUSBx history, hospitalization within 1 month, and diabetes. In univariate analysis, a high incidence of complications was observed for asymptomatic pyuria cases. Therefore, detailed caution is required for patients with such factors during TRUSBx.

• Keywords: Prostatic neoplasms; Biopsy; Complications