"Although of advances in medical environment we are faced with new pathogen in hospital according to increase of antimicrobial resistance, invasive procedure, population of old men, abuse of immune suppressants. Nosocomial infections are more common phenomena than other infection in clinical practice. Therefore, we should know about the exact definition, diagnostic principles, need of control of nosocomial infection. Especially, We need to understand about it in Korea. So the Korean Society for Nosocomial Infection Control (KOSNIC) organized the Korean Nosocomial Infectious Surveillance System (KONIS) to establish a nationwide database of nosocomial infection rate on the intensive care units of hospitals in Korea. This article focuses on the definition, background, principles of diagnosis, the current status and counterplans of nosocomial infection in Korea. We have full assurance that it should provide a theoretical strategy to enforce the infection control."