Extracorporeal shock wave therapy (ESWT) is an effective, safe, and non-invasive modality for pain relief and tissue regeneration. Because, ESWT is used on various medical areas and many diseases, but its use is limited on genitourinary disease, except urinary stone. However, many studies about efficacy of ESWT in chronic prostatitis, Peyronie's disease, and erectile dysfunction are published recently. Many people are suffering from these diseases all over the world, but these diseases are difficult to treat effectively by previous therapy, so ESWT will be able to be an alternative treatment for them. Of course, the physiology of ESWT is not confirmed to be a standard treatment scientifically, therefore it is necessary to make a greater effort to investigate it.