Abstract

"Purpose: We studied the changes in antibiotic sensitivity to causative organisms of urinary tract infection for the past 4 years, in order to provide useful information on the choice of adequate drugs for the treatment of urinary tract infection (UTI). Materials and Methods: We analyzed 7,938 uropathogens and their antibiotic sensitivities in 5,609 patients admitted or visited our hospital (located in the southern area of Kyoung-Gi Do) with more than 105cfu/ml of urine culture from January 2006 to December 2009 retrospectively. Results: The incidence of UTI increased with age and was highest in the first decade (33.0%), followed by seventh decade (11.9%). The most common pathogenic organism was E. coli (43.4%), followed by Klebsiella (13.6%), Enterococcus (7.9%), Staphylococcus (4.8%) and Serratia (4.6%). The incidence of E. coli and Klebsiella increased from respectively 39.3% and 10.1% in 2006, to 46.7% and 14.3% in 2009, while the incidence of Enterococcus and Staphylococcus decreased. In E. coli, resistance to antimicrobial agents was increased in ampicillin (69.6 to 72.0%), ciprofloxacin (38.4 to 47.0%), ceftazidime (12.3 to 19.0%), but decreased in trimethoprim/sulfamethoxazole (42.1 to 37%) and sensitivity to amikacine was above 90%. For the Gram-positive organisms, vancomycin and teicoplanin showed higher sensitivities. Conclusions: E. coli is the most common causative organism of UTI and its resistance to antimicrobial agents is increasing. Fluoroquinolone use should be restricted due to high resistance and economic. The use of amikacin or trimethoprim/sulfamethoxazole as empirical treatment for UTI should be considered. "

• Keywords: Urinary tract infections, Antibiotics, Sensitivity