Systemic lupus erythematosus (SLE) is a disease of unknown cause which involves various organs and primary involvement of urinary bladder is very rare. We experienced a case of a girl aged 12 years who was diagnosed as SLE associated with paralytic ileus and urologic manifestations (interstitial cystitis, hydroureters and hydronephrosis). To our knowledge, the combination of paralytic ileus and interstitial cystitis is quite uncommon in pediatric-onset SLE.