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Anti-Inflammatory Effect of Phlorotannin on Chronic Nonbacterial Prostatitis in a Rat Model
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Yun Seok Jung, Yong-Hyun Cho, Chang Hee Han
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Korean J Urogenit Tract Infect Inflamm 2014;9(2):86-92. Published online October 31, 2014
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Chronic nonbacterial prostatitis and chronic pelvic pain syndrome account for 90-95% of all prostatitis. Little is known about its pathophysiology, thus, various treatments are used. Ecklonia cava, a seaweed, is a member of the brown algae family; many recent reports have demonstrated that its extract containing phlorotannin has anti-oxidative and anti-inflammatory properties. Using the hormone-induced prostatitis rat model, we investigated the anti-inflammatory effects of E. cava extracts via its anti-oxidative process on chronic nonbacterial prostatitis. Materials and Methods: Forty, 10-week-old male white Wistar rats were utilized, and divided equally into the following five groups: 1) control, 2) E. cava-fed, 3) hormone-induced prostatitis (HIP), 4) E. cava-treated HIP, and 5) nonsteroidal anti-inflammatory drug (NSAID)-treated HIP. Results: The results showed statistically-significant improvement in the tissue response to the hormone-induced inflammation among the E. cava-treated and NSAID-treated groups (p＜0.05). Lower malonedialdehyde levels were observed in the group with E. cava-treated HIP than with HIP alone, which was statistically significant. We believe that this supports the anti-oxidative properties of E. cava. Conclusions: This study demonstrates that phlorotannin has anti-inflammatory properties via its anti-oxidative process, which we expect to play an important role in prevention and as an adjuvant therapy for chronic nonbacterial prostatitis.
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Clinical Characteristics of Prostatic Abscess Treated with Transurethral Resection or Incision and Drainage
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Yun Seok Jung, Jang Chun Woo, Yong Seok Lee, Sung Hak Kang, Chang Hee Han, Yong-Hyun Cho
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Korean J Urogenit Tract Infect Inflamm 2009;4(1):67-71. Published online April 30, 2009
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- "Purpose: To evaluate the clinical presentations of prostatic abscess treated with transurethral resection or incision and drainage. Materials and Methods: We retrospectively assessed the charts of 5 patients with the diagnosis of prostatic abscess and treated with transurethral resection or incision and drainage from January 2008 to March 2009. Factors analyzed included presenting features, predisposing factors, radiologic imaging, bacteriological profile, and treatment. Results: The mean patients' age was 58.8 years. Diabetes mellitus was the most common predisposing factor (40%). Four patients presented lower urinary tract symptoms and fever, and three patients had chill. The mean size of prostatic abscess was 3.82cm and four patients had leukocytosis and pyuria. Abscess was drained by transurethral resection of prostate in three cases, and by transurethral incision and drainage in two cases. There were no postoperative complications with complete abscess resolution in all patients. Conclusions: Transurethral resection or incision and drainage should be considered in a patient with large prostatic abscess, which is not responsive to the appropriate antibiotic therapy."
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Experimental Animal Models of Prostatitis: Limitations and Potential
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Yun Seok Jung, Chang Hee Han, Yong-Hyun Cho
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Korean J Urogenit Tract Infect Inflamm 2008;3(1):10-23. Published online April 30, 2008
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- Prostatitis is a polyetiological inflammation of the prostate gland in men characterized by pelvic pain, irritative voiding symptoms, and sexual dysfunction. Histologically prostatitis is characterized by poly- and mononuclear cell infiltrates (neutrophils, lymphocytes, macrophages and plasma cells) in the stromal connective tissue around the acini or ducts. Prostatitis is an important worldwide health problem in men. The pathogenesis and diagnostic criteria for the condition are obscure, with the result that the development of management programs for this condition has been hindered. Animal model(s) might be useful in elucidating mechanisms involved in the molecular pathogenesis of chronic nonbacterial prostatitis and chronic pelvic pain syndrome. Given that prostatitis might have a multifactorial etiology, several animal models with unique features may prove helpful. This review examines a number of experimental animal models of prostatitis and evaluates their advantages and limitations.
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