Urogenital Tract Infection

Young Hwii Ko

6 Articles

Intraurethral Instillation of 5-fluorouracil with Suprapubic Cystostomy for Intraurethral Condyloma Acuminatum: Jong Gyun Ha, Young Hwii Ko, Yeong Uk Kim; Urogenit Tract Infect 2023;18(1):32-34. Published online April 30, 2023; DOI: https://doi.org/10.14777/uti.2023.18.1.32

Abstract PDF PubReader ePub: Condyloma acuminatum is a common sexually transmitted disease caused by the human papillomavirus and with a high recurrence rate in the urethra. We report the intraurethral instillation of 5-fluorouracil cream for intraurethral condyloma acuminatum with suprapubic cystostomy after transurethral surgery. A 64-year-old man had gross hematuria for several days. At cystourethroscopy, multiple papillary mass lesions were identified on the entire urethra. Transurethral resection of the urethral masses confirmed the diagnosis of condyloma acuminatum. However, recurrent multiple warts were identified on the whole urethra. After re-surgery, intraurethral instillation of 5-fluorouracil cream with suprapubic cystostomy was achieved to prevent a recurrence. After one year of 5-fluorouracil instillation, there was no recurrence of intraurethral condyloma acuminatum.

Host-Pathogen Interactions in Urinary Tract Infections: Young Hwii Ko, Jae Young Choi, Phil Hyun Song; Urogenit Tract Infect 2019;14(3):71-79. Published online December 31, 2019; DOI: https://doi.org/10.14777/uti.2019.14.3.71

Abstract PDF: Urinary tract infections (UTIs) are classified by the host condition. Uncomplicated infections are caused most commonly by uropathogenic Escherichia coli (UPEC) and affect otherwise healthy people, whereas complicated infections are commonly caused by species, such as Proteus mirabilis, and affect patients with underlying difficulties, such as a urinary tract abnormality or catheterization. The outcome of infection caused by these bacteria is dictated by the immune response to the UTI and the host factors that influence the susceptibility to disease. This review focuses on the host pathogen interactions in UTI, including an identification of additional virulence factors and therapeutic or prophylactic targets, particularly by UPEC and P. mirabilis.

Recurrent Urinary Tract Infection by Bladder Stone Resulting from Subureteral Injection Polydimethylsiloxane (Macroplastique^®) for Treatment of Vesicoureteral Reflux: Jae Young Choi, Hyun Tae Kim, Young Hwii Ko, Young Hwan Lee, Phil Hyun Song; Urogenit Tract Infect 2016;11(2):62-65. Published online August 31, 2016

Abstract PDF: While endoscopic subureteral injection of bulking agents has become a first-line therapy for the treatment of vesicoureteral reflux (VUR), mainly due to its high success rates with minimal complications, polydimethylsiloxane (PDS) administration can be associated with bladder calcification in a minority of patients. A 10-year-old girl with prior history of subureteral administration of PDS as a treatment modality for bilateral VUR six years ago showed recurrent lower urinary tract symptoms, including dysuria, frequency, and urgency, for the past 6 months. She was admitted to our institution for right pyelonephritis with hydronephrosis. Radiologic examination had revealed two yellowish impacted stones attached to the previous site of PDS administration without recurrence of VUR. The stones were completely removed by cystolitholapaxy. This study suggests that such a late-complication should be considered in patients with recurrent urinary tract infection or lower urinary tract symptom despite complete disappearance of VUR by prior subureteral administration therapy.

Clinical Significance of Toll-Like Receptor and Toll-Like Receptor Blocker: Jae Young Choi, Phil Hyun Song, Young Hwii Ko; Urogenit Tract Infect 2016;11(1):1-6. Published online April 30, 2016

Abstract PDF: The mammalian Toll-like receptor (TLR) family, consisting of 13 members, plays an important role in innate recognition of specific patterns of microbial products. TLR-dependent recognition subsequently causes an activation of antigen-specific adaptive immunity. TLR-mediated signaling pathways consist of two pathways that induce gene expression: the myeloid differentiation primary response gene 88 (MyD88)-dependent pathway and Toll/interleukin-1 receptor-domain containing adaptor protein-inducing interferon--dependent pathway. Synthetic TLR agonists, as well as TLR antagonists, affect and manipulate the host defense systems, and some of these immunomodulating agents may help to overcome intrinsic disturbances of the TLR system to offer new treatment options in urinary tract infection (UTI). Future studies are necessary to clarify additional associations between TLRs and severity of UTI, which may help in developing new treatment options.

Current Updates in Pharmacokinetics and Pharmacodynamics of Fluoroquinolones: Young Hwii Ko, Phil Hyun Song; Korean J Urogenit Tract Infect Inflamm 2015;10(1):1-6. Published online April 30, 2015

Abstract PDF: The ultimate goal of antimicrobial treatment is to decrease the morbidity and mortality related to infection. Maximizing these outcomes requires an understanding of the complex interactions between the drug administered, the host, and the infecting pathogen. Pharmacokinetics, which deals with the disposition of a drug in the body, focuses on such parameters as absorption, distribution, and elimination. Pharmacodynamics more specifically focuses on the interaction between the drug concentration at the site of action over time and the resulting antimicrobial effect. Use of quinolones has increased in vitro activity against several important pathogenic organisms as well as augmented pharmacokinetic parameters. These properties result in enhanced pharmacodynamic characteristics and should improve therapeutic outcomes against selected pathogens. In this article the pharmacokinetics and pharmacodynamic potential of these quinolones, particularly fluoroquinolones, is reviewed.

Renal Venous Perforation during Reinsertion of a Percutaneous Nephrostomy Catheter: hil Hyun Song, Young Hwii Ko, Bong Gi Ok, Yeong Uk Kim, Kwon Soo Lee, Dae Hyeon Kwon, Hyun Tae Kim, Sin-Youl Park, Hee Chang Jung; Korean J Urogenit Tract Infect Inflamm 2014;9(1):56-59. Published online April 30, 2014

Abstract PDF: While the sustainment of percutaneous nephrostomy with regular change in chronic un-operable cases is widely performed for relief of urinary obstructions, performance of the blind procedure without fluoroscopic monitoring could result in clinical disaster. We report on a case of direct renal vein injury by mis-guidance of a nephrostomy catheter, which was successfully managed conservatively by serial venography monitoring combined with intensive conservative treatment. To the best of our knowledge, this is the first report on management of a renal vein injury during the percutaneous nephrostomy.

Author Index