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Risk Factor Associated with Recurrence after OM-89 (Uro-Vaxom®) Treatment for Female Recurrent Cystitis
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Ji-Yeon Han
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Urogenit Tract Infect 2019;14(2):42-45. Published online August 30, 2019
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DOI: https://doi.org/10.14777/uti.2019.14.2.42
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 Abstract
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- Purpose: This study evaluated the risk factors associated with recurrence OM-89 (Uro-Vaxom®) treatment for female recurrent cystitis.
Materials and Methods: The medical records of patients who received OM-89 for at least six months were reviewed retrospectively. Patients were excluded from the analysis if they had an abnormal lower urinary tract anatomy, residual urine volume ≥200 ml, a history of genitourinary tuberculosis, urological cancer or pelvic radiation, indwelling urinary catheter, or had genitourinary surgery within the previous six months. Patients were categorized into two groups: (1) no recurrence and (2) recurrent cystitis after OM-89. The risk factors in the two groups were compared. The recurrent cystitis was defined as two more infections in six months or three or more in one year.
Results: A total of 52 female were included. Group 1 had 35 (67.3%) patients and group 2 had 17 (32.7%) patients. Before and after the OM-89, the mean cystitis episodes for six months of groups 1 and 2 were 4.19±4.60 (range, 2-24) and 1.17±1.79 (range, 0-6), respectively, which were decreased significantly (p <0.001). For recurrence after the OM-89, the only risk factor was uncontrolled diabetes (fasting plasma glucose level >120 mg/dl±casual plasma glucose >180 mg/dl) (p=0.002). No significant differences in the age, menopause, daily water intake, hormone replacement therapy or history of extended-spectrum beta-lactamase-producing Escherichia coli were observed between the two groups.
Conclusions: OM-89 was effective in the management of recurrent cystitis in female. On the other hand, uncontrolled diabetes was a risk factor for treatment failure of OM-89.
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Recurrent Urinary Tract Infection from Urethral Mesh Erosion after Midurethral Mesh Sling Surgery
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Ji-Yeon Han
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Urogenit Tract Infect 2019;14(2):60-63. Published online August 30, 2019
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DOI: https://doi.org/10.14777/uti.2019.14.2.60
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Abstract
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- This paper presents three cases of recurrent urinary tract infections from urethral mesh erosion after transobturator midurethral sling (MUS) surgery. The patients were operated on using a MUS with a mesh for stress urinary incontinence. A few years after surgery (0.3 to 7 years), patients complained of recurrent pain in the urethra with voiding symptoms. In all cases, urethrocystoscopy was performed and an erosion of the sling directly across the urethra was found. Patients were managed by dissecting the urethra and removing the mesh via the transvaginal approach under general anesthesia.
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